Here's the scenario:
I had a ListView control in a Visual Web Part running in SharePoint 2010 with a script manager on the page - but my List View would only display correctly on page load, and after one paging command, then no longer.
With the power of the internet, I came across a very similar situation and resolution online.
It turns out that while I checked everything in the ASP.NET pipeline, I had just assumed that because I was inserting this webpart into an existing site I'd be all set up for jQuery, but turns out I was getting script errors due to the missing jQuery reference.
Yay for collective experience!